Children’s NSAIDs: Interview with Dr. Misurac
Decoded Science had the opportunity to interview Dr. Jason Misurac, Pediatric Nephrology Fellow at Riley Hospital for Children at Indiana University Health regarding the study.
Dr. Misurac explained that there is a correlation between dehydration, giving children NSAIDS, and kidney damage:
“When a patient is dehydrated, the kidney receives less blood flow. The kidney protects itself by increasing blood flow to the kidney’s filters (glomeruli). One important way that the kidney increases blood flow to the glomeruli is through production of prostaglandins within the kidney. Elsewhere in the body, prostaglandins cause pain, inflammation, and fever.NSAIDs, such as ibuprofen and naproxen, block the production of prostaglandins. In this way, ibuprofen and naproxen block an important protection the kidney has against decreased blood flow. Acetaminophen does not cause the same kind of kidney damage.”
“I recommend that parents keep their children well hydrated through use of electrolyte containing solutions such as Pedialyte, especially if they are having vomiting and diarrhea, which predispose to dehydration. Fever can indicate a harmful infection, but by itself is not harmful to the body. A higher fever can indicate a more severe infection, but cannot harm the body. If a child has been drinking well, has normal urine production, and does not have significant vomiting or diarrhea, then ibuprofen or naproxen are fine to give in recommended doses and intervals. However, if the child is not drinking well, is having significant diarrhea or vomiting, or has decreased urine production, then acetaminophen might be a better first choice. Of course, they should seek care or advice from a pediatrician if the child has signs or symptoms of dehydration.”
Flu and Norovirus
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