I asked Dr. Jones how CAPE would be used to treat prostate cancer, and what the next steps would be to making this available as a treatment options. Dr. Jones responded:
“CAPE could potentially be taken orally for prostate cancer prevention, or could be administered orally; intravenously; alone; or as an adjuvant therapy with other anti-cancer agents. While CAPE is not so soluble in water, it has been dissolved in oil and administered to mice. Oral administration of CAPE to mice has been shown to reduce tumor growth and metastases of gliomas, colon, breast, prostate, and liver cancers.
The next step to making this a treatment option for cancer patients would likely be the identification of a clinician willing to enroll patients to test the efficacy of CAPE in reduction of early stage prostate cancer.”
With this exciting new treatment, I asked Dr. Jones if CAPE would be a treatment option for other cancers. Dr. Jones said:
“Yes, while our study showed that CAPE was more potent at inhibiting the growth of early stage prostate cancer cells versus other types of cancer cells grown in the lab, our work and work of others has indicated that CAPE administered to mice can stop the growh of gliomas, colon, prostate, liver, and other types of cancer.”
Cancer Treatment: Caffeic acid phenethyl ester
This study shows the importance of how some natural remedies can be used in traditional medicine. Using CAPE, combined with other treatment methods, may become more mainstream in the medical field. As Dr. Jones told Decoded Science:
“CAPE, like many other natural products, has been used medicinally for years with only a vague understanding of the molecular mechanisms by which it works. We are very hopeful that our new high-throughput protein analysis approach, termed micro-western arrays, will be useful to determine the systematic molecular nature by which CAPE and other natural products act so that we can begin to incorporate them into 21stcentury medical practice.”
Chih-Pin Chuu, Hui-Ping Lin, et al. Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks. (2012). Cancer Prevention Research. Accessed May 4, 2012.
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